解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:The purpose of our study was to investigate the immunohistochemical expression of TGF-beta1 and p27 in pancreatic adenocarcinomas and to compare the findings with the clinicopathological features and survival. We also aimed to evaluate the expression of TGF-beta1 and p27 in the context of other cell cycle an...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-5-98
更新日期:2005-08-08 00:00:00
abstract:BACKGROUND:Cancer patients may harbor micrometastases that remain dormant, clinically undetectable during a variable period of time. A traumatic event or surgery may trigger the balance towards tumor growth as a result of associated angiogenesis, cytokine and growth factors release. CASE PRESENTATION:We describe a pat...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-5-94
更新日期:2005-08-04 00:00:00
abstract:BACKGROUND:Data concerning incidence and prevalence of cancer in the different regions of Russia have traditionally not been provided on a basis that facilitated comparison with data from countries in western parts of Europe. The oncological hospital in Arkhangelsk, in co-operation with Universitetet i Tromsø (Norway),...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-5-82
更新日期:2005-07-19 00:00:00
abstract:BACKGROUND:Tumor resistance to chemotherapy may be present at the beginning of treatment, develop during treatment, or become apparent on re-treatment of the patient. The mechanisms involved are usually inferred from experiments with cell lines, as studies in tumor-derived cells are difficult. Studies of human tumors s...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-5-78
更新日期:2005-07-18 00:00:00
abstract:BACKGROUND:Medical oncologists continue to use performance status as a proxy for quality of life (QOL) measures, as completion of QOL instruments is perceived as time consuming, may measure aspects of QOL not affected by cancer therapy, and interpretation may be unclear. The pulse oximeter is widely used in clinical pr...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-5-72
更新日期:2005-07-06 00:00:00
abstract:BACKGROUND:Downstream of Ras, the serine/threonine kinase B-raf has been reported to be mutated, among other carcinomas, in a substantial subset of primary melanomas with a preponderance of mutations within the kinase domain including the activating V599E and V599K transitions. METHODS:We here investigated a represent...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-5-58
更新日期:2005-06-03 00:00:00
abstract:BACKGROUND:Sentinel lymph node (SLN) biopsy is an effective tool for axillary staging in patients with invasive breast cancer. This procedure has been recently proposed as part of the treatment for patients with ductal carcinoma in situ (DCIS), because cases of undetected invasive foci and nodal metastases occasionally...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-5-28
更新日期:2005-03-11 00:00:00
abstract:BACKGROUND:Cancer of unknown primary remains a mallignancy of elusive biology and grim prognosis that lacks effective therapeutic options. We investigated angiogenesis in cancer of unknown primary to expand our knowledge on the biology of these tumors and identify potential therapeutic targets. METHODS:Paraffin embedd...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-5-25
更新日期:2005-03-03 00:00:00
abstract:BACKGROUND:Desmoid tumour is a benign, non metastasising neoplasm characterised by an elevated deposition of organic macromolecules in the extracellular matrix (ECM). The matrix metalloproteinases (MMPs) are a family of zinc-dependent proteinases involved in the degradation of ECM macromolecules. The MMPs and their nat...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-5-22
更新日期:2005-03-01 00:00:00
abstract:BACKGROUND:Serine-threonine kinases of the Raf family (A-Raf, B-Raf, C-Raf) are central players in cellular signal transduction, and thus often causally involved in the development of cancer when mutated or over-expressed. Therefore these proteins are potential targets for immunotherapy and a possible basis for vaccine...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-5-15
更新日期:2005-02-09 00:00:00
abstract:BACKGROUND:We describe a patient who underwent transurethral resection of the prostate for urinary obstructive symptoms and had histological findings of adenocarcinoma of the prostate with prostatic localization of chronic lymphocitic leukemia (CLL). The contemporary presence of CLL, adenocarcinoma of the prostate and ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-4-95
更新日期:2004-12-22 00:00:00
abstract:BACKGROUND:BAG-1 is a multifunctional co-chaperone of heat shock proteins (Hsc70/Hsp70) that is expressed in most cells. It interacts with Bcl-2 and Raf indicating that it might connect protein folding with other signaling pathways. Evidence that BAG-1 expression is frequently altered in human cancers, in particular in...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-4-85
更新日期:2004-11-24 00:00:00
abstract:BACKGROUND:The management of unresectable or metastatic gastrointestinal stromal tumors (GISTs) has previously been difficult as they are resistant to conventional chemotherapy and radiation. The development of imatinib mesylate has made a major impact on the management of advanced GISTs. It is apparent that there are ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-4-74
更新日期:2004-10-09 00:00:00
abstract:BACKGROUND:Although modest improvements in the survival of patients with non-small cell lung cancer (NSCLC) can be achieved with cisplatin-based chemotherapy (CT), its value is disputed in the geriatric setting. In this study, we evaluate the feasibility of vinorelbine/cisplatin CT for elderly NSCLC patients. METHODS:...
journal_title:BMC cancer
pub_type: 临床试验,杂志文章
doi:10.1186/1471-2407-4-69
更新日期:2004-09-29 00:00:00
abstract:BACKGROUND:Following resection of liver metastases from colorectal cancer, 5-year survivals are reportedly 30 - 39%. It can be assumed that this clinical situation represents systemic disease. Therefore, it is postulated that systemic chemotherapy would improve outcomes, particularly in those whose disease is sensitive...
journal_title:BMC cancer
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1186/1471-2407-4-32
更新日期:2004-07-10 00:00:00
abstract:BACKGROUND:Multidrug resistance (MDR) is a phenomenon that is often associated with decreased intracellular drug accumulation in patient's tumor cells resulting from enhanced drug efflux. It is related to the overexpression of a membrane protein, P-glycoprotein (Pgp-170), thereby reducing drug cytotoxicity. A variety o...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-4-13
更新日期:2004-04-17 00:00:00
abstract:BACKGROUND:Adoptive immunotherapy with cytotoxic T lymphocytes (CTL) represents an alternative approach to treating solid tumors. Ideally, this would confer long-term protection against tumor. We previously demonstrated that in vitro-generated tumor-specific CTL from the ovalbumin (OVA)-specific OT-I T cell receptor tr...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-3-21
更新日期:2003-07-28 00:00:00
abstract:BACKGROUND:Most staging systems for soft tissue sarcoma are based on histologic malignancy-grade, tumor size and tumor depth. These factors are generally dichotomized, size at 5 cm. We believe it is unlikely that tumor depth per se should influence a tumor's metastatic capability. Therefore we hypothesized that the unf...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-3-17
更新日期:2003-05-26 00:00:00
abstract:BACKGROUND:The evaluation of cancer patients needs, especially during that delicate period when they are hospitalized, allows the identification of those areas of care that require to be improved. Aims of the study were to evaluate the needs in cancer inpatients and to improve the understanding of the meanings of the n...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-3-12
更新日期:2003-04-23 00:00:00
abstract:BACKGROUND:A number of osteoblastic meningiomas, primary osteosarcomas of the meninges, and post-radiation osteosarcomas of the head have been reported. However, postradiation dedifferentiation of meningioma into osteosarcoma has not been reported previously. CASE PRESENTATION:In 1987 a caucasian man, then 38 years ol...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-2-34
更新日期:2002-12-03 00:00:00
abstract:BACKGROUND:Intrahepatic cholangiocarcinomas are malignant tumors arising from the intrahepatic biliary tract. The pathogenesis of these tumors remains unknown. Although there is a marked global variation in prevalence, some recent studies have suggested an increase in mortality from intrahepatic cholangiocarcinoma in s...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-2-10
更新日期:2002-05-03 00:00:00
abstract:BACKGROUND:It is known that amino acid oxidation is increased in tumor-bearing rat muscles and that leucine is an important ketogenic amino acid that provides energy to the skeletal muscle. METHODS:To evaluate the effects of a leucine supplemented diet on the intestinal absorption alterations produced by Walker 256, g...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-2-7
更新日期:2002-04-15 00:00:00